A dual dynamically cross-linked hydrogel promotes rheumatoid arthritis repair through ROS initiative regulation and microenvironment modulation-independent triptolide release.

High oxidative stress and inflammatory cell infiltration are major causes of the persistent bone erosion and difficult tissue regeneration in rheumatoid arthritis (RA). Triptolide (TPL) has become a highly anticipated anti-rheumatic drug due to its excellent immunomodulatory and anti-inflammatory effects. However, the sudden drug accumulation caused by the binding of "stimulus-response" and "drug release" in a general smart delivery system is difficult to meet the shortcoming of extreme toxicity and the demand for long-term administration of TPL. Herein, we developed a dual dynamically cross-linked hydrogel (SPT@TPL), which demonstrated sensitive RA microenvironment regulation and microenvironment modulation-independent TPL release for 30 days. The abundant borate ester/tea polyphenol units in SPT@TPL possessed the capability to respond and regulate high reactive oxygen species (ROS) levels on-demand. Meanwhile, based on its dense dual crosslinked structure as well as the spontaneous healing behavior of numerous intermolecular hydrogen bonds formed after the breakage of borate ester, TPL could remain stable and slowly release under high ROS environments of RA, which dramatically reduced the risk of TPL exerting toxicity while maximized its long-term efficacy. Through the dual effects of ROS regulation and TPL sustained-release, SPT@TPL alleviated oxidative stress and reprogrammed macrophages into M2 phenotype, showing marked inhibition of inflammation and optimal regeneration of articular cartilage in RA rat model. In conclusion, this hydrogel platform with both microenvironment initiative regulation and TPL long-term sustained release provides a potential scheme for rheumatoid arthritis.

Molecular subtype identification and prognosis stratification by a immunogenic cell death-related gene expression signature in colorectal cancer.

OBJECTIVES: This study intended to develop a new immunogenic cell death (ICD)-related prognostic signature for colorectal cancer (CRC) patients. RESEARCH DESIGN AND METHODS: The Non-Negative Matrix Factorization (NMF) algorithm was adopted to cluster tumor samples based on ICD gene expression to obtain ICD-related subtypes. Survival analysis and immune microenvironment analysis were conducted among different subtypes. Regression analysis was used to construct the model. Based on riskscore median, cancer patients were classified into high and low risk groups, and independent prognostic ability of the model was analyzed. The CIBERSORT algorithm was adopted to determine the immune infiltration level of both groups. RESULTS: We analyzed the differential genes between cluster 4 and cluster 1-3 and obtained 12 genes with the best prognostic features finally (NLGN1, SLC30A3, C3orf20, ADAD2, ATOH1, ATP6V1B1, KCNQ2, MUCL3, RGCC, CLEC17A, COL6A5, and INSL4). In addition, patients with lower risk had higher levels of infiltration of most immune cells, lower Tumor Immune Dysfunction and Exclusion (TIDE) level and higher immunophenscore (IPS) level than those with higher risk. CONCLUSIONS: This study constructed and validated the ICD feature signature predicting CRC prognosis and provide a reference criteria for guiding the prognosis and immunotherapy of CRC cancer patients.

Evaluating the impact of China's MSW sorting pilot policy on urban sustainable development: Empirical evidence from 95 cities.

The escalating challenge of municipal solid waste (MSW) critically tests the sustainable development capacities of urban centers. In response, China initiated pilot policies in 2017 aimed at bolstering MSW management. The effectiveness of these initiatives, however, necessitates empirical scrutiny. This study leverages panel data spanning 95 cities at the prefectural level or higher, covering the period from 2006 to 2020, to assess the impact of the MSW sorting pilot policy on urban sustainable development using a difference-in-differences approach. The research found that the MSW sorting pilot policy has significantly increased the processing volume of MSW, thereby enhancing the sustainable development capabilities of cities. Further, the study identifies augmented fixed asset investments as a key mechanism through which pilot cities have enhanced their MSW management capabilities. Notably, the policy's stimulative effects are more pronounced in less densely populated and economically lagging regions. These findings provide critical insights for developing nations in shaping MSW sorting strategies and advancing urban sustainability.

Development of Cyclic N,O-Aminal-Embedded Bis-tetrahydroisoquinoline Analogues as Potential DNA Alkylation Agents.

This work described a novel "functional hybrid" design for bis-tetrahydroisoquinoline (bis-THIQ) analogues as potential DNA alkylation agents by replacing the labile C21-carbinolamine on the bis-THIQ skeleton of ET-743 with a chemically stable cyclic N,O-aminal functionality. In vitro anti-proliferation evaluation has proven that it is a successful approach to deliver new bis-THIQ analogues with common cytotoxicities, among which several exhibited sub-micromolar-range IC50 against the proliferation of human cancer cell lines A549, HepG2, and MDA-MB-231, respectively.

Myeloid Cell-Triggered In Situ Cell Engineering for Robust Vaccine-Based Cancer Treatment.

Following the success of the dendritic cell (DC) vaccine, the cell-based tumor vaccine shows its promise as a vaccination strategy. Except for DC cells, targeting other immune cells, especially myeloid cells, is expected to address currently unmet clinical needs (e.g., tumor types, safety issues such as cytokine storms, and therapeutic benefits). Here, it is shown that an in situ injected macroporous myeloid cell adoptive scaffold (MAS) not only actively delivers antigens (Ags) that are triggered by scaffold-infiltrating cell surface thiol groups but also releases granulocyte-macrophage colony-stimulating factor and other adjuvant combos. Consequently, this promotes cell differentiation, activation, and migration from the produced monocyte and DC vaccines (MASVax) to stimulate antitumor T-cell immunity. Neoantigen-based MASVax combined with immune checkpoint blockade induces rejection of established tumors and long-term immune protection. The combined depletion of immunosuppressive myeloid cells further enhances the efficacy of MASVax, indicating the potential of myeloid cell-based therapies for immune enhancement and normalization treatment of cancer.

Isochromenylium/Isoquinolinium-Mediated One-Pot Annulation to Hexahydropyrazinoisoquinolines. Synthesis of Quinocarcinol.

A novel annulation protocol has been successfully developed in this work for the quick generation of 1,3,4,6,11,11a-hexahydro-2H-pyrazino[1,2-b]isoquinolines from easily accessible o-alkynylbenzaldehydes. Various hexahydropyrazinoisoquinolines, including those previously unavailable with electron-deficient substituents, have been achieved via the newly developed continuously operational isochromenylium/isoquinolinium-mediated procedure. It also perfectly served as a key step to generate the basic skeleton in the new total synthesis of quinocarcinol, accompanied by the development and application of a direct late-stage stereoselective sp3 C-H hydroxymethylation.

Origin of the Anomalous Electrical Transports in Quasi-One-Dimensional Ta2NiSe7.

Exploration of exotic transport behavior is of great interest and importance for revealing the properties of the CDW phase of quasi-one-dimensional Ta2NiSe7. We report the anisotropic electrical transport properties of Ta2NiSe7 single crystals in the CDW phase. The anisotropic constant (γ = ρb/ρc) increased rapidly at TCDW = 60 K upon cooling. The results of the Hall resistivity show that both the concentrations and mobilities of carriers change abruptly at TCDW. The out-of-plane AMR exhibits C2 and C4 symmetry components while the in-plane AMR exhibits C2, C4, and C6 at the CDW state. The planar Hall effect is observed in Ta2NiSe7 at low temperature, which is suggested to originate from the anisotropic orbital magnetoresistance. The calculated results show that the Fermi surface of Ta2NiSe7 was slightly reconstructed due to the CDW transition. This work highlights the enhancement of Fermi surface anisotropy during CDW formation and provides a novel approach to study the CDW materials.

Exploring the Profile Contributions in Meyerozyma guilliermondii YB4 under Different NaCl Concentrations Using GC-MS Combined with GC-IMS and an Electronic Nose.

Using Meyerozyma guilliermondii YB4, which was isolated and screened from southern Sichuan pickles in the laboratory, as the experimental group, we investigated the changes in growth, total ester content, and volatile flavor substances of M. guilliermondii YB4 under different NaCl concentrations. The growth of M. guilliermondii YB4 was found to be inhibited by NaCl, and the degree of inhibition increased at higher NaCl concentrations. Additionally, the total ester content of the control group (CK) was significantly lower compared to the other groups (p < 0.05). The application of NaCl also resulted in distinct changes in the volatile profile of YB4, as evidenced by E-nose results. Gas chromatography-mass spectrometry (GC-MS) and gas chromatography-ion mobility spectrometry (GC-IMS) were employed to analyze the volatile compounds. A total of 148 and 86 volatiles were detected and identified using GC-MS and GC-IMS, respectively. Differential volatiles among the various NaCl concentrations in YB4 were determined by a variable importance in projection (VIP) analysis in partial least squares-discriminant analysis (PLS-DA). These differentially expressed volatiles were further confirmed by their relative odor activity value (ROAV) and odor description. Ten key contributing volatiles were identified, including ethanol, 1-pentanol, nonanal, octanal, isoamyl acetate, palmitic acid ethyl ester, acrolein, ethyl isobutanoate, prop-1-ene-3,3'-thiobis, and 2-acetylpyrazine. This study provides insights into the specificities and contributions of volatiles in YB4 under different NaCl concentrations. These findings offer valuable information for the development of aroma-producing yeast agents and the subsequent enhancement in the flavor of southern Sichuan pickles.

MLAM: Multi-Layer Attention Module for Radar Extrapolation Based on Spatiotemporal Sequence Neural Network.

Precipitation nowcasting is mainly achieved by the radar echo extrapolation method. Due to the timing characteristics of radar echo extrapolation, convolutional recurrent neural networks (ConvRNNs) have been used to solve the task. Most ConvRNNs have been proven to perform far better than traditional optical flow methods, but they still have fatal problems. These models lack differentiation in the prediction of echoes of different intensities, which leads to the omission of responses from regions with high intensities. Moreover, because it is difficult for these models to capture long-term feature dependencies among multiple echo maps, the extrapolation effect declines sharply over time. This paper proposes an embedded multi-layer attention module (MLAM) to address the shortcomings of ConvRNNs. Specifically, an MLAM mainly enhances attention to critical regions in echo images and the processing of long-term spatiotemporal features through the interaction between input and memory features in the current moment. Comprehensive experiments were conducted on the radar dataset HKO-7 provided by the Hong Kong Observatory and the radar dataset HMB provided by the Hunan Meteorological Bureau. Experiments show that ConvRNNs embedded with MLAMs achieve more advanced results than standard ConvRNNs.

Glycyrrhizin inhibits LPS-induced inflammatory responses in goat ruminal epithelial cells in vitro.

Inflammation plays a crucial role in the progression of Subacute Ruminal Acidosis (SARA). The experiment was designed to investigate anti-inflammatory effects of glycyrrhizin on goats ruminal epithelial cells (GREC) which were induced SARA by Lipopolysaccharide (LPS) in vitro. The GREC were induced SARA by adding LPS at the concentration of 5 µm and glycyrrhizin was added at different concentration of 0, 60, 90, 120, 150 µm. The structural integrity of LPS-induced GREC with the treatment of glycyrrhizin were observed by electron microscope; The levels of inflammatory factors TNF-α, IL-1ß, IL-6, IL-8 and IL-12 were measured by ELISA; The number of Zo-1 and Occludin were measured, the expression of tight junction protein Occludin were measured by Western blot, and the mRNA expression of NF-κB, TNF-α, IL-1ß, IL-6, IL-8 and IL-12 were measured in vitro. The results showed that higher concentration treatment of glycyrrhizin led to better morphology in LPS-induced GREC. Glycyrrhizin inhibited the growth of inflammatory factors TNF-α, IL-1ß, IL-6, IL-8 and IL-12 in a dose-dependent manner. The number of ZO-1 and Occludin increased with the increase of adding of glycyrrhizin. Western blot analysis showed that the expression of tight junction protein Occludin in LPS-induced GREC increased with the adding of glycyrrhizin in a dose-dependent manner. Furthermore, the mRNA expression of NF-κB, TNF-α, IL-1ß, IL-6, IL-8 and IL-12 decreased significantly with the increase treatment of glycyrrhizin. Glycyrrhizin significantly inhibits LPS-induced inflammatory mediators in GREC and the effects are better with the increase treatment of glycyrrhizin in vitro.

Revealing mechanisms of triclosan on the removal and distribution of nitrogen and phosphorus in microalgal-bacterial symbiosis system.

Microalgal-bacterial symbiosis (MABS) system performs synergistic effect on the reduction of nutrients and carbon emissions in the water treatment process. However, antimicrobial agents are frequently detected in water, which influence the performance of MABS system. In this study, triclosan (TCS) was selected to reveal the effects and mechanisms of antimicrobial agents on MABS system. Results showed that the removal efficiencies of chemical oxygen demand, NH4+-N and total phosphorus decreased by 3.0%, 24.0% and 14.3% under TCS stress. In contrast, there were no significant decrease on the removal effect of total nitrogen. Mechanism analysis showed that both the growth rate of microorganisms and the nutrients retention capacity of extracellular polymeric substances were decreased. The intracellular accumulation for nitrogen and phosphorus was promoted due to the increased cytomembrane permeability caused by lipid peroxidation. Moreover, microalgae were dominant in MABS system with ratio between microalgae and bacteria of more than 5.49. The main genus was Parachlorella, with abundance of more than 90%. Parachlorella was highly tolerant to TCS, which might be conductive to maintain its survival. This study revealed the nutrients pathways of MABS system under TCS stress, and helped to optimize the operation of MABS system.

Li0.5La0.5TiO3 as an Ionic Conducting Additive Enhancing the High-Voltage Performance of LiNi0.8Mn0.1Co0.1O2 Cathodes in Lithium-Ion Batteries.

Although high-voltage (e.g., >4.3 VvsLi) operation can increase specific capacity and energy of Ni-rich NMC cathodes, it accelerates the oxidative decomposition of electrolytes and surface degradation of NMC cathodes, leading to rapid capacity fading. This work presents a novel approach that employs Li0.5La0.5TiO3 (LLTO) solid-electrolyte as a Li-ion conductor and surface passivation agent to stabilize the cathode/electrolyte interphase (CEI) layer of the LiNi0.8Mn0.1Co0.1O2 (NMC811) cathode and enhance its high-voltage performances. The LLTO particles improve Li-ion transportation across the CEI layer, as evidenced by its reduced impedance in Nyquist plots. Furthermore, passivation of CEI by LLTO mitigates parasitic reactions (e.g., transition metal dissolution) that occur on the graphite solid electrolyte interphase layer during extended cycles of pouch-cells. As a result, pouch-cells with the 1 or 5 wt % LLTO-blended NMC811 cathodes can deliver 19-23% increase in specific capacity and improved cycle life (1000 cycles) at high voltages (up to 4.4 V), comparing to bare NMC811 cathodes. Post-mortem characterization of pouch-cells quantitatively identified the degradation sources of NMC811 cathode at high-voltages, which highlighted the improvement mechanisms of LLTO blended-cathodes.

DARMF-UNet: A dual-branch attention-guided refinement network with multi-scale features fusion U-Net for gland segmentation.

Accurate gland segmentation is critical in determining adenocarcinoma. Automatic gland segmentation methods currently suffer from challenges such as less accurate edge segmentation, easy mis-segmentation, and incomplete segmentation. To solve these problems, this paper proposes a novel gland segmentation network Dual-branch Attention-guided Refinement and Multi-scale Features Fusion U-Net (DARMF-UNet), which fuses multi-scale features using deep supervision. At the first three layers of feature concatenation, a Coordinate Parallel Attention (CPA) is proposed to guide the network to focus on the key regions. A Dense Atrous Convolution (DAC) block is used in the fourth layer of feature concatenation to perform multi-scale features extraction and obtain global information. A hybrid loss function is adopted to calculate the loss of each segmentation result of the network to achieve deep supervision and improve the accuracy of segmentation. Finally, the segmentation results at different scales in each part of the network are fused to obtain the final gland segmentation result. The experimental results on the gland datasets Warwick-QU and Crag show that the network improves in terms of the evaluation metrics of F1 Score, Object Dice, Object Hausdorff, and the segmentation effect is better than the state-of-the-art network models.

UV-Curing-Enhanced Organic Long-Persistent Luminescence Materials.

Amorphous organic long-persistent luminescence materials (OLPLMs) can realize simpler solution processing and large-area uniform luminescence, where the luminescent properties are significantly influenced by the rigid environment. However, research on utilizing the rigidity to promote long-persistent luminescence (LPL) properties of amorphous OLPLMs is still relatively rare due to the lack of an unambiguous and effective strategy to construct the rigid environment. Here, a universal strategy is proposed to enhance the LPL performance of organic host-guest doping systems by UV curing, which utilizes the rigid environment constructed by UV curing to promote the interaction between host and guest, thus inducing a generation of materials with highly efficient LPL performance. This solution-processable, large-area, and "easy-to-realize" material fabrication strategy can make amorphous OLPLMs show broader application prospects in some fields, such as anti-counterfeiting, nondestructive detection, and pattern marking or indication.

Insights into roles of triclosan in microalgal-bacterial symbiosis system treating wastewater.

Triclosan (TCS) is an antimicrobial agent and frequently detected in wastewater or water body. This study investigated the role of TCS in microalgal-bacterial symbiosis (MABS) system treating wastewater. The results showed that the removal efficiencies of NH4+-N, total nitrogen, and total phosphorus decreased under increased TCS stress, with decrease ratios of 26.5%, 16.9%, and 34.7%. The activities of microalgae were more affected than that of bacteria. The secretion of extracellular polymeric substances (EPSs) and activity of superoxide dismutase firstly increased and then decreased with aggravated TCS stress, while the accumulation of malondialdehyde increased, leading to increased permeability of cytomembrane and bioaccumulation of TCS. In addition, the aggregation properties of microalgae and bacteria were enhanced with TCS loading increasing, and the migration of TCS was affected by enhanced EPSs secretions and MABS aggregates. This work may provide some new insights into the roles of TCS in MABS system.

Reconstruction of Metal Ions Extracted from Coal Gangue to Synthesize Cost-effective Adsorbent for Highly Efficient Removal of Pollutants.

An emerging "one stone, three birds" strategy was proposed to realize the value-added disposal of solid waste coal gangue (CG), the synthesis of superb adsorbent and the efficient decontamination of pollutants (i. e., dyes, heavy metals). In this process, the metal ions extrated from calcined coal gangue (CCG) was reconstituted by a one-step hydrothermal process to yield porous polymetallic silicate adsorbent (named HECCGA8h). The adsorbent has a high adsorption capacity of 270.27 and 185.53 mg/g for methylene blue (MB) and Cd(II), respectively. In the actual waters, the removal rate of MB by this adsorbent reaches 99.8% (in Yangtze River water) and 99.42% (in Seawater), and the removal rate of Cd(II) reaches 99.11% (in Yangtze River water) and 92.52% (in Seawater), respectively. Thermokinetic analysis showed that the adsorption of MB by HECCGA8h is spontaneous and endothermic with increased entropy, and the adsorption of Cd(II) is spontaneous and exothermic. The adsorption of MB is mainly driven by synergism of hydrogen bond, electrostatic attraction and ion exchange, and the adsorption of Cd(II) is mainly driven by the complexation and ion exchange between the surface group of the adsorbent and Cd(II). This research provides a new way for the realization of "treating waste with waste".

Matrine-induced nephrotoxicity via GSK-3ß/nrf2-mediated mitochondria-dependent apoptosis.

INTRODUCTION: Matrine (MT), an ingredient extracted from the Chinese herb Sophora flavescens, can result in nephrotoxicity because of long-term exposure. However, the underlying mechanism by which MT leads to kidney injury remains unclear. This study aimed to investigate the roles of oxidative stress and mitochondria in MT-induced kidney toxicity both in vitro and in vivo. METHODS: Mice were exposed to MT for 20 days, and NRK-52E cells were exposed to MT with or without LiCl (a GSK-3ß inhibitor), tert-Butylhydroquinone (t-BHQ, an Nrf2 activator), or small interfering RNA. RESULTS: The results showed that MT caused nephrotoxicity accompanied by an increase in reactive oxygen species (ROS) accumulation and mitochondrial dysfunction. Meanwhile, MT significantly upregulated glycogen synthase kinase-3ß (GSK-3ß) activity, released cytochrome c (Cyt C) and cleaved caspase-3, decreased the activity of nuclear factor-erythroid 2-related Factor 2 (Nrf2), and reduced the expression of heme oxygenase-1 (HO-1) and NAD(P)H:quinone oxidoreductase 1 (NQO-1), which led to the inactivation of antioxidant enzymes and the activation of apoptosis. In addition, GSK-3ß inhibition by LiCl or small interfering RNA pretreatment or Nrf2 activation by t-BHQ pretreatment attenuated the toxic effects of MT in NRK-52E cells. CONCLUSIONS: Taken together, these results revealed that MT-induced apoptosis triggered kidney toxicity and that GSK-3ß or Nrf2 might serve as a promising nephroprotective target for MT-induced kidney injury.

Analysis of the Low-Carbon Transition Effect and Development Pattern of Green Credit for Prefecture-Level Cities in the Yellow River Basin.

Green credit is a vital instrument for promoting low-carbon transition. However, designing a reasonable development pattern and efficiently allocating limited resources has become a challenge for developing countries. The Yellow River Basin, a critical component of the low-carbon transition in China, is still in the early stages of green credit development. Most cities in this region lack green credit development plans that suit their economic conditions. This study examined the impact of green credit on carbon emission intensity and utilized a k-means clustering algorithm to categorize the green credit development patterns of 98 prefecture-level cities in the Yellow River Basin based on four static indicators and four dynamic indicators. Regression results based on city-level panel data from 2006 to 2020 demonstrated that the development of green credit in the Yellow River Basin can effectively reduce local carbon emission intensity and promote low-carbon transition. We classified the development patterns of green credit in the Yellow River Basin into five types: mechanism construction, product innovation, consumer business expansion, rapid growth, and stable growth. Moreover, we have put forward specific policy suggestions for cities with different development patterns. The design process of this green credit development patterns is characterized by its ability to achieve meaningful outcomes while relying on fewer numbers of indicators. Furthermore, this approach boasts a significant degree of explanatory power, which may assist policy makers in comprehending the underlying mechanisms of regional low-carbon governance. Our findings provide a new perspective for the study of sustainable finance.

Exploring the key factors of schizophrenia relapse by integrating LC-MS/1H NMR metabolomics and weighted correlation network analysis.

BACKGROUND: Lack of comprehending key factors of schizophrenia relapse has impeded its effective treatment, indicating that the mechanism clarification and available intervention of schizophrenia relapse required further amelioration. METHOD: Based on the integration of LC-MS and 1H NMR metabolomics, a weighted correlation network was established to screen pivotal factors of accelerating schizophrenia relapse. Then, the cluster most correlated with schizophrenia relapse was explored, and the biological function of cluster was investigated. Next, the key biomarker related to schizophrenia relapse was obtained through multiple algorithms. Moreover, the Lilikoi algorithm and correlation analysis were implemented to reveal the association between key biomarker and schizophrenia relapse. RESULT: Results showed that 458 different forms of metabolites were identified for structuring the weighted correlation network. The module-trait correlation indicated that the turquoise module was the most highly correlated with schizophrenia relapse. Further, network analysis revealed that, in turquoise module, cluster 1 composed of 139 metabolites (involved in lipid metabolism and energy metabolism) was the most important subnetwork relevant to schizophrenia relapse. Finally, phenylalanylphenylalanine was recommended as the key biomarker related to schizophrenia relapse. Moreover, the correlation analysis indicated that phenylalanylphenylalanine might affect the progression of schizophrenia by intervening in energy metabolism. CONCLUSION: In summary, critical factors of schizophrenia relapse have been revealed in our research, expounding the schizophrenia progression more systemically, which could shed some light on improving the intervention of schizophrenia relapse.

Origin of the Anomalous Electrical Transport Behavior in Fe-Intercalated Weyl Semimetal Td -MoTe2.

Weyl semimetal Td -MoTe2 has recently attracted much attention due to its intriguing electronic properties and potential applications in spintronics. Here, Fe-intercalated Td -Fex MoTe2 single crystals (0 < x < 0.15 ) are grown successfully. The electrical and thermoelectric transport results consistently demonstrate that the phase transition temperature TS is gradually suppressed with increasing x. Theoretical calculation suggests that the increased energy of the Td phase, enhanced transition barrier, and more occupied bands in 1T' phase is responsible for the suppression in TS . In addition, a ρα -lnT behavior induced by Kondo effect is observed with x ≥ 0.08, due to the coupling between conduction carriers and the local magnetic moments of intercalated Fe atoms. For Td -Fe0.15 MoTe2 , a spin-glass transition occurs at ≈10 K. The calculated band structure of Td -Fe0.25 MoTe2 shows that two flat bands exist near the Fermi level, which are mainly contributed by the dyz and d x 2 - y 2 ${{\rm{d}}_{{x^2} - {y^2}}}$ orbitals of the Fe atoms. Finally, the electronic phase diagram of Td -Fex MoTe2 is established for the first time. This work provides a new route to control the structural instability and explore exotic electronic states for transition-metal dichalcogenides.